What is synthesis of estrone?

Estrone is a natural estrogen hormone that is synthesized in the body from androstenedione or testosterone. However, it can also be synthesized artificially in the laboratory. The synthesis of estrone involves a series of chemical reactions, which can differ based on the starting material used. One common method of synthesis involves the conversion of 4-androstene-3,17-dione to estrone through a series of oxidation and reduction reactions. Another method involves the transformation of cholesterol to estrone via a similar series of chemical reactions. The resulting estrone produced can be purified through various methods such as recrystallization or column chromatography. Estrone is used in therapeutic applications, such as hormonal replacement therapy or as a treatment for breast cancer.